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Topic Title: hydrogel & skin regeneration
Created On: 08/19/2013 12:13 PM
 09/13/2013 02:11 PM

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Repola, thank you so much for the update. It seems as if hydrogel holds much promise for significant burning and scarring.

I must admit, I pray computer models one day take the place of live animals when it comes to experimentation and determining the safety/efficacy of new products and procedures. My heart has a special affinity for furry, feathered, and scaled creatures, and I hate that they might suffer.

Nonetheless, I also feel for burn and wound victims and believe products that encourage self-healing are quite hopeful. God bless.
 08/28/2013 03:08 PM

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Dear Cher 777,

Seams they are going to start the trials on bigger animals (pigs), and the last step will be in humans.
Of course it is a milestone becouse it is the firt time full regeneration on a third degree burn even in animals.
They need more trials, tests and ajustments but full skin regeneration in humans will be possible.
When? I do not know, I hope soon.
 08/26/2013 01:14 PM

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From what I understand, dextran-hydrogel-based material speeds healing and augments the ability of regenerated skin to function as it should. It enables hasty growth of new blood vessels which, in turn, encourages faster wound healing.

Nonetheless, the trials that I am privy to were not human-based. Is there any information (e,g., a human study) that suggests people will react in the same way as animals? If so, this sounds like an exciting milestone in wound healing.

Please share additional info if/when available. Thanks.
 08/23/2013 03:46 PM

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Neovascularization is a critical determinant of wound-healing outcomes for deep burn injuries. We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to promote neovascularization and skin regeneration in third-degree burn wounds. Dextran hydrogels are soft and pliable, offering opportunities to improve the management of burn wound treatment. We first developed a procedure to treat burn wounds on mice with dextran hydrogels. In this procedure, we followed clinical practice of wound excision to remove full-thickness burned skin, and then covered the wound with the dextran hydrogel and a dressing layer. Our procedure allows the hydrogel to remain intact and securely in place during the entire healing period, thus offering opportunities to simplify the management of burn wound treatment. A 3-week comparative study indicated that dextran hydrogel promoted dermal regeneration with complete skin appendages. The hydrogel scaffold facilitated early inflammatory cell infiltration that led to its rapid degradation, promoting the infiltration of angiogenic cells into the healing wounds. Endothelial cells homed into the hydrogel scaffolds to enable neovascularization by day 7, resulting in an increased blood flow significantly greater than treated and untreated controls. By day 21, burn wounds treated with hydrogel developed a mature epithelial structure with hair follicles and sebaceous glands. After 5 weeks of treatment, the hydrogel scaffolds promoted new hair growth and epidermal morphology and thickness similar to normal mouse skin. Collectively, our evidence shows that customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds.
 08/19/2013 12:13 PM

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